5/1/2016
Oakland A's sign Joey Butler and release Dan Robertson

Pittsburgh Pirates release Tony Sanchez and Deolis Guerra and sign Kirby Yates and Tyler Holt

5/8/2016
Tampa Bay Rays sign Alex Pressley and release Jemile Weeks

5/18/2016
Atlanta Braves sign Darwin Barney

5/21/2016
Pittsburgh Pirates sign Alex Pressley and release James Jones

5/22/2016
Cincinnati Reds trade Jerome Williams to the Arizona Diamondbacks for Ryan Burr

5/31/2016
San Francisco Giants release Juan Perez